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Caterpillar Fungus May Transform Cancer Treatment

New research demonstrates how a chemical produced by a caterpillar fungus shows promise as a possible cancer treatment by revealing how it interacts with genes to interrupt cell growth signals.

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PacBio Launches Vega Benchtop, Hopes People Get “Hooked on HiFi”

One thing ASHG attendees have grown to count on is PacBio creating a buzz. And this year is no exception. The company launched its latest instrument with a party and concert by One Republic on Wednesday evening.

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Inscripta Reports Successful Scaleup of an Anti-Aging Skincare Ingredient

Commercial biomanufacturing addresses serious challenges in sourcing plant-based ingredients, according to a spokesperson at Inscripta, including the environmental footprint associated with current extractive sourcing and the limited depth and consistency of supply chains.

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Supplier-Turned-Partner: Twist Joins Absci in AI Antibody Collaboration

The companies have agreed to apply Twist’s silicon-based high-throughput gene synthesis platform and Absci’s Integrated Drug Creation™ platform, aiming to accelerate the design and preclinical development of an antibody therapeutic for an undisclosed set of diseases.

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Cancer-Fighting Zeal Regained by Tired T Cells Deprived of Lactic Acid

Researchers showed how blocking a solute carrier protein can reinvigorate exhausted T cells, which in mouse models of cancer led to improved tumor control, both when used as monotherapy, and also when combined with immunotherapy.

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Genomics in Snowy Denver: A Video Update from ASHG

GEN editors Julianna LeMieux, PhD, and Uduak Thomas take a break at ASHG to discuss some of what they have learned and the trends that they have noticed.

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Targeting CD47 Could Be Critical Step in Attacking Colorectal Cancer

The researchers knew colorectal cancer cells use the immune checkpoint CD47 to dodge macrophages. But how do cancer cells manipulate CD47, and what could this mean when it comes to treating colon cancer?

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Gut Microbiome Changes May Serve as Risk Factors for Rheumatoid Arthritis

Researchers identified changes in the make-up of the gut microbiome prior to onset of clinically evident rheumatoid arthritis in those at risk of the disease, which could feasibly offer up opportunities for preventive and personalized treatment strategies.

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StockWatch: Wall Street Weighs Trump Effect on Biopharma, from Vaccines to M&A

Jefferies analysts Michael J. Yee and Akash Tewari, and Leerink Partners analyst David Risinger, CFA, all pinpointed the most dramatic effect on biopharma coming from the presence of Robert F. Kennedy, Jr., in a yet-to-be-defined role in healthcare.

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Seer Showcases Deep Proteomics Capabilities, Announces Co-Marketing Deal with Thermo Fisher Scientific

At ASHG, Seer highlighted how its deep proteomics technology helps scientists gain insights into neurodegenerative conditions, cancer, and metabolic conditions. The company also has a deal to pair its Proteograph product with Thermo’s Orbitrap Astral mass spectrometers.

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Improving the Manufacture of mRNA Biologics

This November issue article provides production tips from Crystal Bio, TriLink Biotechnologies, Ginkgo Bioworks, Quantoom Biosciences, and Parexel.

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Flow Cytometry Balances Complexity and Accessibility

Despite the dazzle of its spectral capabilities, flow cytometry is helping users focus on their research, clinical, and diagnostic applications.

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Direct RNA Sequencing Supports Novel Discoveries in RNA Biology

Years of experiments and databases filled with RNA-seq results belie the simple reality that, until fairly recently, it was impossible to analyze RNA directly. The RNA-seq studies performed with conventional sequencing platforms are based entirely on cDNA, an imperfect proxy for RNA that requires scientists to infer knowledge about the original RNA molecule rather than […]

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Omics Data Analysis: A Range of Options

Data analysis experts share their views on open source software, commercial software, cloud-based platforms, and outsourcing solutions.

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MRSA Deploys Two-Fold Defense Strategy to Resist Antibiotic Treatments

Besides the established route that uses a new enzyme to make its cell walls, new research shows MRSA has also evolved an alternative division mechanism that allows it to replicate in the presence of antibiotics.

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