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Scientists mapped the human maternal–fetal interface in unprecedented detail, identifying new cell types and mechanisms underlying pregnancy complications like preeclampsia, miscarriage, and preterm birth, improving understanding of healthy and disrupted development.
The new portal was designed to extend internal workflows to support external collaborators. With this structured approach, labs experience increased efficiency while minimizing version conflicts, human error, and compliance risks.
Under the terms of the partnership, Seer's Proteograph product suite will be used to profile the plasma proteome in samples from 10,000 participants from the PRECISE-SG100k initiative.
Study showed that Cholera bacteria can efficiently acquire genetic elements from extracellular DNA released by other cholerae strains and non-cholera vibrio species, potentially adding to their own antiviral defense arsenals.
Understanding the processes of molecular movement across the BBB has been somewhat elusive, but a new technique for identifying the proteins within the luminal surface has been developed by HHMI researchers.
Using rapid protein degradation, chemogenomics, and super‑resolution microscopy in mouse embryonic stem cells, the team dissected the distinct contributions of BRD2 and BRD4 to transcription.
In this episode of GEN's Touching Base, editors discuss a new wave of agentic AI transforming the modern lab, multiple billion-dollar-plus acquisitions, and the dynamic obesity market.
The cryo-EM technology is designed to provide detailed insights across the R&D value chain—from epitope mapping and hit generation to structure-guided lead optimization and candidate selection.
Cryo-EM study reveals the first detailed structure of the Bornavirus nucleoprotein–RNA complex, uncovering unique RNA binding and assembly mechanisms that advance understanding of viral replication and antiviral targets.
Researchers have found that the human gut microbiome and epigenetics are intertwined, and that both contribute to early life neurodevelopment, and potentially to the development of ASD and ADHD.
Today’s organoid companies underscore proof points in the ability to model complex human biology with high fidelity. At the same time, the government’s evolving regulatory stance is serving as a critical catalyst, providing both validation and momentum to accelerate widespread adoption of these platforms.
In this Point of View column, Mike Garrett, CEO of Taconic Biosciences, explores redefining preclinical models for the future of drug development. The question is no longer whether animal models still have a place in modern drug development, but how they can be used more judiciously and responsibly. When integration guides decision-making, the result is a more efficient therapeutic pipeline, greater regulatory confidence, and meaningful progress toward the goals of the 3Rs. A win for science; a win for patients; and, ultimately, a win for animals.
Researchers developed novel, first-in-class drugs that inhibit both HIF-1 and HIF-2 and which, combined with immunotherapy, eliminated breast, colorectal, melanoma, and prostate tumors in mice, suggesting that the drugs could eventually be used to treat a broad range of cancers in humans.
Researchers developed a method to assemble n-doped poly(benzodifurandione) (n-PBDF) in vivo from injected monomers, using an organism’s native catalysts, specifically, abundant hemoproteins, to build conductive polymers directly in the brain.
For the genomics community February means the season of big announcements as the AGBT meeting—which has earned a reputation for breaking field-shaping news—takes place. The meeting is packed not only with technology announcements in the sponsor suites, but also with scientific talks in the sessions to showcase how the technology is being used to address new biological questions. This year's meeting did not disappoint.
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