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A GWAS meta-analysis including 2.5 million individuals identified 26 genetic risk factors linked with fibromyalgia, identifying risk variants in 26 regions of the genome, many which are involved in brain and nerve function.
Elix and the University of Vienna will partner to bridge the gap between advanced structural biology and artificial intelligence. By integrating AI’s predictive power with experimental atomic-resolution data, the project seeks to bypass the limitations of traditional drug discovery, delivering new therapeutic insights for complex diseases.
LTG-001 achieved the primary endpoint of the Phase IIb LTG-001-010 trial (NCT07102459) by achieving better-than-placebo scores in the time-weighted sum of the pain-intensity difference (SPID) over the 48-hour treatment period (SPID48), based on the 0-10 range of scores of the Numeric Pain Rating Scale, with higher SPID48 values indicating greater pain reduction.
Crosstalk between mitochondrial metabolism and epigenetic regulation helps activate the inflammatory SASP in senescent cells, revealing a potential therapeutic target for limiting chronic inflammation during aging.
Scientists developed a platform, GOOSE, allowing them to design disordered proteins at a large scale, offering a lens through which to investigate how their component sequences affect the cell and how changes in such proteins might drive diseases.
The team integrated high-resolution spatial transcriptomics, single-cell RNA sequencing, and chromatin-accessibility profiling across nine sequential stages of lung colonization in mouse models.
In this episode of GEN's Touching Base, editors discuss business news from Axiom and Latigo, and science updates on the potential roots of fibromyalgia and base editing for Huntington’s disease.
The metabolite 10-hydroxystearic acid (10-HSA), from Lactiplantibacillus plantarum, repaired HIV-related gut damage, reduced inflammation, restored immunity, and improved antiretroviral therapy effectiveness in preclinical primate studies, supporting future human trials.
Through a multistep process, signals from infected cells trigger the formation of a receptor complex that directs neutrophils out of blood vessels toward infection sites without damaging healthy tissue.
A study in mice has shown how shown that microglia immune cells in the brain play a critical role in how the brain recovers from ketamine anesthesia, and indicates that there are differences between female and male brains.
The Palo Alto-based company is developing small molecule drugs that modulate the transcriptome. The latest funding raise will advance IND-enabling studies and clinical preparation of its neurological disease portfolio.
Researchers identified a form of transmissible cancer in a freshwater fish species, in which the cancer cells behave more like parasites than conventional tumors, moving from fish to fish.
Samsung views the deal as expanding its capabilities beyond antibodies and ADCs to include peptide therapeutics, while advancing innovation across high-growth areas such as oncology and other emerging indications.
An analysis of aging human brains revealed widespread immune remodeling, blood-brain barrier deterioration, and genome architecture changes, challenging long-held assumptions about how the brain's resident immune cells are maintained.
Solar energy generates electricity to produce hydrogen, which combines with carbon dioxide to make methanol. Specialized enzymes then convert methanol into specific amino acids, depending on the enzyme combination used.
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