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A study has shown how part of the bird retina operates under conditions of chronic oxygen deprivation, overturning a long-standing assumption about a mysterious structure in the bird eye, and providing insights that might inform on future stroke therapy research.
Chai Discovery, Noetik, and Boltz have entered multi-year pharma partnerships focused on models, not molecules, signaling a cultural shift away from single-asset bets and toward investment in AI infrastructure for broad discovery.
Differentiation mechanisms of oligodendrocyte precursors (OPCs) are not well understood. Using gene expression analysis, localization methods and time lapse imagery, OPC differentiation was tracked, clarifying previously unknown mechanisms.
By shifting into an RNA‑binding phase, MYC‑driven tumors eliminate R‑loop–derived alarm signals and stay hidden from immune attack, exposing a selective vulnerability that may help make MYC‑high cancers detectable again.
Research in mice and children demonstrated that disease-associated gut bacteria can be detected through VOCs in exhaled breath, potentially paving the way developing rapid, noninvasive breath tests to monitor and diagnose gut health issues linked to disease.
It has been widely known that manufacturing costs and variability are major challenges to the widespread adoption of cell and gene therapies. These challenges have limited broader access to advanced therapies.
Individuals with Down syndrome experience significant alterations in liver metabolism. A new study suggests that these changes may be modifiable through diet, providing hope for improved health outcomes.
Experimental CAR T cell immunotherapy targeting tumor-associated macrophages promoted tumor clearance and increased survival in preclinical models of metastatic ovarian and lung cancer, pointing to a new potential strategy for treating advanced-stage solid tumors.
Scientists tested kaempferol, a natural compound found in vegetables like kale and broccoli. In laboratory models with drug-resistant human lung tumors, daily treatment with kaempferol significantly shrank tumors over 24 days.
A link between increased colorectal cancer risk and inflammatory bowel disease is found in TL1A-driven immune signaling and tumor-promoting neutrophils, highlighting potential therapeutic targets.
Researchers developed disease‑responsive nanoparticles in mouse models that home to damaged cartilage and deliver mRNA therapy precisely where osteoarthritis is most severe, offering a new strategy for targeted, lesion‑specific treatment.
By inhibiting the enzyme sEH and boosting epoxy-oxylinpins levels, scientists have shown that it is possible to lower levels of specific immune cells linked to chronic inflammation.
Development of these NGS workflows reflects growing demand across genomics research and core facilities for standardized automated protocols that improve consistency while reducing hands-on time as sequencing volumes continue to increase.
By keeping our focus on the human genome—arguably the most important and historically sensitive genome to work on—we’ll ensure the field stays ambitious, responsible, and aimed at solving the problems that matter most to us. And it doesn’t matter which group crosses the line first. Humanity is the winner.
UC San Diego researchers are leading a $25.8 million ARPA-H–funded effort to 3D bioprint patient-specific, transplantable human livers, aiming to eliminate organ shortages and improve outcomes for liver failure patients.
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