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Preclinical study results suggest how the heart can keep itself well-fueled even under times of stress, by burning glucose in the cell cytosol while burning lactate in the mitochondria.
By optimizing laser, optical, and acquisition parameters, The Rockefeller University researchers developed a three-photon microscopy platform that captures deep-brain neural activity in living mice at single-cell resolution without surgically removing the overlying cortex.
GEN's Kevin Davies, PhD, reports from ESGCT where patient safety, expanding access to gene therapy, and progress towards an HIV vaccine were prominent themes among the early talks at ESGCT 2026.
This eBook brings together perspectives from across the AAV development and manufacturing continuum. It explores how early commercial planning can help avoid costly delays, how standardized platform approaches and off-the-shelf plasmids can streamline development, and how next-generation innovations are helping overcome long-standing manufacturing bottlenecks.
Researchers created the first comprehensive whole-body single-cell atlas of an adult vertebrate, the tiny, transparent fish Danionella cerebrum, offering a new resource for studying brain regeneration, cellular diversity, and investigating how different tissues function together.
In developing fetuses, the human brain generates an excess of neurons, most of which are eliminated around when the baby is born. New research suggests that this is an important quality-control mechanism.
Liu ensured that his return visit to ESGCT (having spoken at the congress in Barcelona in 2019) would be one of the highlights of the conference. The “meta lesson” of the past few years in therapeutic genome editing is that different scientific approaches and applications can synergize with regulatory, manufacturing, and economic advances “to achieve the mission we’re on.”
Scientists identified a potential therapeutic target for pancreatic ductal cell adenocarcinoma, discovering that the protein ANO6 is involved in a process helping pancreatic cancer cells obtain nutrients from surrounding cells, while suppressing the immune system’s ability to fight tumors.
Parse Biosciences and Nomic Bio are partnering to create Cascade, a 100-million-cell multimodal dataset combining single-cell and proteomic data to advance AI-driven immune modeling, drug discovery, and therapeutic target identification.
According to the company, the funds will support the next phase of its growth in enabling autonomous science in labs and biopharmaceutical companies using its AI and robotics systems.
Researchers also developed a clinical obesity polygenic score that combined information from numerous genetic variants, a score that was shown to be significantly associated with BMI, body fat percentage, and waist circumference.
The results of a preclinical study suggest that the BCG vaccine, which is widely used to prevent tuberculosis and treat bladder cancer, may also have properties that reduce the risk for dementia by inducing trained immunity.
ASHG President Susan Slaugenhaupt, PhD, opened the society’s Montreal meeting with a heartfelt address emphasizing hope, leadership, and the importance of communication amid the challenges facing science today.
A year-long collaboration involving scientists at PerturbAI, OpenAI, and their other institutions yielded an AI reasoning framework that turns datasets into testable hypotheses, with thousands of agents analyzing whole-brain genomic data in minutes instead of months.
RFD4-Proteina is an open model based on Nvidia’s NVIDIA BioNeMo™ artificial intelligence (AI) platform for chemistry and biology that combines programmable protein design with search capabilities. RFD4-Proteina generates targeted protein designs, enabling scientists and agents to search and refine those designs using molecular inputs, constraints, and scoring objectives.
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