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The results of a mouse study suggest that inflammation during pregnancy can trigger autism-like brain and behavior changes in offspring, and that the effects may be rapidly but temporarily reversible in adulthood with a dose of the immunosuppressive drug rapamycin.
Using single-cell multiomics, spatial transcriptomics, and an AI model called Hicformer, the team generated a multiscale view connecting genome structure, gene regulation, and tissue organization in Alzheimer’s disease.
Atlases like this one can provide the labeled, cell-type-resolved training data that artificial intelligence models need to make accurate predictions—a bottleneck that has historically limited the field.
An oral antiviral candidate prevented airborne and contact transmission of a measles-like virus in ferrets, reduced disease severity and infectious duration, and could complement vaccination strategies to help control future measles outbreaks.
Researchers generated off-the-shelf, mass-producible iPSC-derived allogeneic γδT cells that in a small preclinical study suppressed tumor growth in mouse colorectal cancer xenograft models, highlighting the cells’ potential as a novel immunotherapy for colorectal cancer.
A human study showed that heart attack patients had higher levels of micro- and nanoplastics in their blood, compared with patients diagnosed with chronic ischemic heart disease and normal controls.
The combined solution using Constellation and autoloMATE overcomes fragmentation, limited visibility, and the absence of standardized, interoperable data flows without replacing existing processes, enabling manufacturers to scale to commercially viable levels.
Researchers developed a series of light-activated small molecule drugs that mimic the function of the light-sensing photoreceptor cells that degenerate in diseases such as age-related macular degeneration and retinitis pigmentosa, and which in tests restored sight in blind mice.
Scientists used artificial intelligence to design CRISPR nucleases with properties not found in nature, achieving activity that matches or exceeds natural enzymes despite the proteins' complex, multi-domain structure.
The team’s strategy—called antibody–ADC click—relies on the rapid ligation between trans‑cyclooctene (TCO) and tetrazine moieties.
Avenue Biosciences´ machine learning-powered platform engineers and screens signal peptide variants to increase protein secretion from cells. Circio’s circVec technology has demonstrated significantly enhanced and durable gene expression in several tissues.
A first-in-human KRAS-targeted pancreatic cancer prevention vaccine was found to be safe, elicited durable immune responses in 90% of high-risk participants, and showed encouraging signs of slowing or reversing precancerous lesions.
In this episode of GEN's Touching Base, editors talk about neuroscience research updates, insights into how investors are approaching the changing AI landscape, and business updates on profits and buyouts.
Genetic evidence links hyperhidrosis to nerve overstimulation rather than simple sweat gland dysfunction, a finding that could allow existing medicines to be repurposed for targeted treatment.
A study in mice and in human cells found that blocking a single receptor on tissue-resident macrophages promoted clearance of accumulating senescent neutrophils, preserved the youthfulness of multiple organs in mice, and substantially slowed cognitive decline.
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