A new study from Mayo Clinic suggests checkpoint immunotherapy may reshape the immune environment within lymph nodes after melanoma has spread to them. Researchers found that treatment reorganized several types of immune cells and changed the behavior of certain cells, called macrophages, that can either support or suppress an immune response depending on their environment.
A patient has undergone pioneering stem-cell therapy to treat Parkinson's disease, the Japanese drugmaker behind the treatment said on Friday, in a world first following its conditional approval in the country.
Persistent fatigue, shortness of breath, difficulty concentrating, anxiety or low mood: Many people continue to suffer from symptoms months after a COVID-19 infection, significantly restricting their daily lives. However, reliable data on which treatments are effective remain scarce.
Once a supplement favored mainly by fitness fanatics, creatine has quickly become one of the most widely used dietary add-ons in the world.
"The Fireside Database: Large-Scale Evidence from 25,419 Psychedelic Support Interactions," published in Science Advances, provides researchers and policymakers with an empirical window into psychedelic use and support outside clinical settings.
Researchers at the Max Delbrück Center and University Medical Center Hamburg-Eppendorf have traced how herpes simplex virus 1 infection progresses among neighboring skin cells in skin organoids. The work is published in Science Advances.
Millions of people take antihistamines for allergies, but some of these medicines can make you sleepy, slow your reactions and affect your concentration. Others are much less likely to have these effects. Knowing the difference can help you choose an allergy treatment that won't interfere with your day.
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults and is one of the most aggressive and deadly forms of cancer. It is difficult for surgeons to fully remove GBM because it often has microscopic "tentacles" that extend from the tumor into healthy brain tissue. GBM is also hard to treat because it creates an immunosuppressive microenvironment that helps the cancer evade immune attack and resist therapy.
For patients undergoing elective intestinal resection for Crohn disease (CD), cumulative surgical recurrence rates are lower with laparoscopic versus open surgery, according to a study published online July 23 in Techniques in Coloproctology.
Up to three-quarters of all women will experience a genital yeast infection at least once in their lives. Recurrent infections, in particular, can significantly impair quality of life. The typical symptoms—such as itching, burning, and pain—are caused not only by the yeast Candida albicans, but, more importantly, by an excessive immune response. But why is the immune reaction in these cases so intense and persistent? An international research team led by the Leibniz-HKI has now uncovered how the host protein albumin fuels the inflammatory cascade while simultaneously shielding the fungal pathogen from the immune system. The findings have been published in Nature Communications.
For patients with inflammatory bowel disease (IBD), predictors of renal dysfunction have been identified and include osteoporosis, enteral nutrition, and intestinal surgery, according to a study published in BMC Gastroenterology.
Amish and Mennonite shoppers in conservative dress mingled with shoppers from the wider public on a recent Friday at a vast outdoor market here, where vendors sold colorful pumpkins and mums, fry pies and squash, sports jerseys and Barbie accessories.
Loneliness has been considered a major health risk for seniors, but a new study suggests younger adults might fare even worse from living by themselves. Living alone appears to increase a person's risk of death from a multitude of causes, particularly among adults 18 to 64, researchers reported in the International Journal of Epidemiology.
Patients with psoriasis have an increased risk for cataracts and cataract surgery, with the risks for these outcomes varying by treatment modality, according to a study published online Oct. 26 in the Journal of Dermatology.
Acute kidney injury (AKI) occurs more often among older patients and men with drug overdose–involved hospitalizations, while severe inpatient courses disproportionately affect younger patients, according to research published in the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.
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